2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-U00050S
    (E)-10-Hydroxynortriptyline-d3
    		99.65%
    (E)-10-Hydroxynortriptyline-d3 is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression[1].
    (E)-10-Hydroxynortriptyline-d<sub>3</sub>
  • HY-B0794
    AZ7550
    AZ7550 is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
    AZ7550
  • HY-101677
    cPrPMEDAP
    		99.62%
    cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin.
    cPrPMEDAP
  • HY-100645
    Trimethoprim 3-oxide
    		≥98.0%
    Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim.
    Trimethoprim 3-oxide
  • HY-137565
    Hydroxy ritonavir
    Hydroxy ritonavir is a metabolite of Ritonavir. Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.
    Hydroxy ritonavir
  • HY-130189
    S-Phenylmercapturic acid
    		99.38%
    S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay.
    S-Phenylmercapturic acid
  • HY-13256A
    Desmethyl Erlotinib
    		98.77%
    Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor. Desmethyl Erlotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Desmethyl Erlotinib
  • HY-W086896
    α-Demethylnaproxen
    		99.68%
    α-Demethylnaproxen is the major metabolite of Nabumetone (HY-B0559), Nabumetone is an orally active COX-2 inhibitor with anti-inflammatory activity.
    α-Demethylnaproxen
  • HY-101723
    Modecainide
    		99.36%
    Modecainide is a major metabolite of Encainide, which is an antiarrhythmic agent.
    Modecainide
  • HY-137963
    Daidzein 4'-β-D-glucuronide
    Daidzein 4'-β-D-glucuronide (Compound M4) is a metabolite of Daidzein (HY-N0019).
    Daidzein 4'-β-D-glucuronide
  • HY-137522A
    Zidovudine O-β-D-glucuronide
    Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.
    Zidovudine O-β-D-glucuronide
  • HY-124414
    4'-Hydroxytamoxifen
    		99.2%
    4'-Hydroxytamoxifen is a metabolite of Tamoxifen. 4'-Hydroxytamoxifen shows higher affinity for the ER than Tamoxifen. 4'-Hydroxytamoxifen induces a non-apoptotic cytotoxic effect in human endometrial adenocarcinoma cells.
    4'-Hydroxytamoxifen
  • HY-136596
    Apalutamide-COOH
    		99.14%
    Apalutamide-COOH is a metabolite of Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM.
    Apalutamide-COOH
  • HY-14572
    PR-104A
    		98.17%
    PR-104A (SN 27858) is the alcohol metabolite of phosphate proagent PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity. PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL).
    PR-104A
  • HY-103005
    Ramelteon metabolite M-II
    		98.24%
    Ramelteon metabolite M-II is the major metabolite of Ramelteon, with IC50s of 208 pM, 1470 pM for human melatonin receptors (MT1 or MT2). Ramelteon is a selective melatonin agonist.
    Ramelteon metabolite M-II
  • HY-136456
    2-NP-AMOZ
    2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ (a metabolite of antibiotic Furaltadone), can be used to detect protein bound AMOZ.
    2-NP-AMOZ
  • HY-W009934
    2-Phenyl-2-(2-pyridyl)acetonitrile
    		99.97%
    2-Phenyl-2-(2-pyridyl)acetonitrile is the major metabolite of SC 15396 metabolized by the supernatant fraction of rat liver homogenate. SC 15396 is an antigastrin that inhibits gastric secretion.
    2-Phenyl-2-(2-pyridyl)acetonitrile
  • HY-136346
    2-Hydroxy atorvastatin lactone
    2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.
    2-Hydroxy atorvastatin lactone
  • HY-12781
    Desbutyl Lumefantrine
    		99.66%
    Desbutyl Lumefantrine is a metabolite of lumefantrine with antimalarial activity.
    Desbutyl Lumefantrine
  • HY-100646
    (E)-10-Hydroxynortriptyline maleate
    (E)-10-Hydroxynortriptyline maleate is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.
    (E)-10-Hydroxynortriptyline maleate
Cat. No. Product Name / Synonyms Application Reactivity